Upregulation of microRNA-23b-3p induced by farnesoid X receptor regulates the proliferation and apoptosis of osteosarcoma cells
نویسندگان
چکیده
منابع مشابه
MicroRNA-199a-3p is downregulated in human osteosarcoma and regulates cell proliferation and migration.
microRNAs (miRNA, miR) play an important role in cancer cell growth and migration; however, the potential roles of miRNAs in osteosarcoma remain largely uncharacterized. By applying a miRNA microarray platform and unsupervised hierarchical clustering analysis, we found that several miRNAs have altered expression levels in osteosarcoma cell lines and tumor tissues when compared with normal human...
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microRNAs (miRNA,miR)playan important role in cancer cell growthandmigration;however, thepotential roles of miRNAs in osteosarcoma remain largely uncharacterized. By applying a miRNAmicroarray platform and unsupervised hierarchical clustering analysis, we found that several miRNAs have altered expression levels in osteosarcoma cell lines and tumor tissues when compared with normal human osteobl...
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miRNAs (microRNAs) are small non-coding RNAs [18-25 nt (nucleotides)] that regulate gene expression mainly through affecting post-transcriptional modification. Osteosarcoma is an aggressive sarcoma of the bone characterized by a high level of genetic instability and recurrent DNA deletions and amplifications. miRNAs play an important role in cancer cell growth and migration; however, the potent...
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Prostate cancer is a form of cancer that develops in the prostate, a gland in the male reproductive system. In the present study, the activation of the farnesoid X receptor (FXR), a member of the nuclear receptor superfamily, was demonstrated to inhibit cell proliferation in LNcaP cells. Using clinical samples, mRNA and protein levels of FXR were found to be significantly decreased by quantitat...
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ژورنال
عنوان ژورنال: Journal of Orthopaedic Surgery and Research
سال: 2019
ISSN: 1749-799X
DOI: 10.1186/s13018-019-1404-6